Down Syndrome

Down syndrome (Trisomy 21): There are 400,000 people in the U.S. living with Trisomy 21 (Down syndrome). In Down syndrome, an over-abundance of interferon- α and interferon- γ receptors encoded on an extra 21st chromosome leads to excessive interferon activity. Meiogen’s trisomy mouse model studies documented dramatically improved development 1 and cultured neuron viability 2 using anti-interferon antibodies. These observations were subsequently confirmed using interferon receptor gene mutations to reduce the bioactivity of both interferon types 3 .