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the indications
There are a significant number of debilitating diseases where the therapeutic use
of an interferon inhibitor is strongly indicated.
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Click on the links to the right to learn more about some of our lead indications:
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AIDS dementia
Of the more than 1.2 million people in the USA living with HIV it is estimated that more than 250,000 suffer
from some form of learning and memory problems of the type often seen in patients treated with interferon for cancer or virus infection.
Scientists at Emory University School of Medicine have presented supporting evidence of interferon-alpha involvement in HIV Associated Neurocognitive Disorder (HAND)
1. In collaboration with Meiogen, we have tested this hypothesis in a HIV brain infected mouse model and
demonstrated the ability of NormferonTM treatment to prevent HIV brain pathology 2
and reverse HIV associated learning difficulties 3.
down syndrome
Down syndrome (Trisomy 21): There are 400,000 people in the U.S.
living with Trisomy 21 (Down syndrome). In Down syndrome, an over-abundance
of interferon- α and interferon-
γ receptors encoded on an extra 21st chromosome leads to excessive interferon
activity. Meiogen’s trisomy mouse model studies documented dramatically improved
development 1
and cultured neuron viability 2
using anti-interferon antibodies. These observations were subsequently
confirmed using interferon receptor gene mutations to reduce the bioactivity of
both interferon types 3.
The possibility that interferon is involved in Down syndrome has now gained support
from trisomy 21 human sample studies at the Crnic Institute for Down Syndrome 4.
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