Autoimmune Disease

  1. Blanco, P., et al., Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science, 2001. 294(5546): p. 1540-3.
  2. Jacob, C.O., P.H. van der Meide, and H.O. McDevitt, In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon. J Exp Med, 1987. 166(3): p. 798-803.
  3. Flores, A. et al., Systemic Lupus Erythematosus Following Interferon Therapy. Br. J Rheumatol 33(8),787 (1994).
  4. Baechler, E.C., et al., Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci U S A, 2003. 100(5): p. 2610-5.


  1. Gringeri, A., et al., Absence of clinical, virological, and immunological signs of progression in HIV-1-infected patients receiving active anti-interferon-alpha immunization: a 30-month follow-up report. J Acquir Immune Defic Syndr Hum Retrovirol, 1996. 13(1): p. 55-67.
  2. Capobianchi, M.R., et al., Coordinate Induction of Interferon alpha and gamma by Recombinant HIV_1 Glycoprotein 120. AIDS Res and Human Retrovir. 9(10), 957-962 (1993)
  3. Francis, M.L., et al., Interferons in the Persistence, Pathogenesis, and Treatment of HIV Infection. AIDS Res and Human Retrovir. 8(2),199-207 (1992).

Down Syndrome

  1. Maroun, L.E., Anti-interferon immunoglobulins can improve the trisomy 16 mouse phenotype. Teratology, 1995. 51(5): p. 329-35.
  2. Hallam, D.M. and L.E. Maroun, Anti-gamma interferon can prevent the premature death of trisomy 16 mouse cortical neurons in culture. Neurosci Lett, 1998. 252(1): p. 17-20.
  3. Maroun, L.E., T.N. Heffernan, and D.M. Hallam, Partial interferon-α/β and -γ receptor knockout trisomy 16 mouse fetuses show improved phenotype and cultured neuron viability. J Interferon Cytokine Res, 2000. 20: p. 197-203.

Transplant Rejection

  1. Slater, A.D., et al., The effects of interferon-alpha/beta in a model of rat heart transplantation. J Heart Lung Transplant, 1992. 11(5): p. 975-8.
  2. Morton, A.J., et al., Association between pretransplant interferon-alpha and outcome after unrelated donor marrow transplantation for chronic myelogenous leukemia in chronic phase. Blood, 1998. 92(2): p. 394-401.
  3. Bren, A., A. Kandus, and D. Ferluga, Rapidly progressive renal graft failure associated with interferon- alpha treatment in a patient with chronic myelogenous leukemia. Clin Nephrol, 1998. 50(4): p. 266-7.
  4. Wiseman, A.C., et al., Donor IFN-gamma receptors are critical for acute CD4(+) T cell-mediated cardiac allograft rejection. J Immunol, 2001. 167(9): p. 5457-63.
  5. Cavet, J., et al., Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation. Blood, 2001. 98(5): p. 1594-600.
  6. Fuller, L., et al., Characterization of anti-canine cytokine monoclonal antibodies specific for IFN-gamma: effect of anti-IFN-gamma on renal transplant rejection. Tissue Antigens, 1994. 43(3): p. 163-9.
  7. Skurkovich, S., et al., Treatment of corneal transplant rejection in humans with anti- interferon-gamma antibodies. Am J Ophthalmol, 2002. 133(6): p. 829-30.